Where: Building 9 Lecture hall 2
Credit: 1
Description
Lecture by Paolo Falcaro, Professor in Bio-based Materials Technology at the Graz University of Technology.
ABOUT THIS EVENT
A recent development in Metal-organic Framework (MOF) research is the preparation of porous biocomposites. Biomolecules can be integrated with MOFs through infiltration, grafting, and encapsulation. In this presentation, we will focus on encapsulation methods by the spontaneous self-assembly around biomacromolecules (e.g. proteins, enzymes, carbohydrates) of Zeolitic Imidazolate Framework-8 (ZIF-8) and related polymorphs. The bioactive properties of such porous bio-composites will be examined and the synergy between biotherapeutics, biocatalysts, and MOFs will be discussed. Then, opportunities towards the extension of MOF biomineralization in complex biological systems (e.g. yeast cells) will be highlighted. Finally, we will focus on the current limitations of these systems as possible challenges for the future progress of MOFs for biotechnology and biomedicine.
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Paolo Falcaro
Paolo Falcaro is a university professor in Bio-based Materials Technology at the Graz University of Technology. He works in the field of self-assembled materials, film deposition and crystal engineering. He received his Ph.D. in Materials Engineering from Bologna University. He has led a research team engineering porous crystals, related inorganic- and bio-composites at CSIRO, Australia. His research focuses mostly on metal organic frameworks (MOFs), mesoporous materials, and functional nanoparticles for application to sensing, environmental remediation, and biotechnology. He develops new crystal growth methodologies and self-assembly strategies to design novel biomacromolecule-based composites for bio-catalysis and bio-medicine.
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