Where: Building 9 Lecture hall 1
Credit: 1
Description
Lecture by Christian Doonan, Professor of Chemistry and Director of the Centre for Advanced Nanomaterials at Adelaide University.
ABOUT THIS LECTURE
Metal-organic Frameworks (MOFs) are well known for their exceptionally high surface areas and modular synthesis. Recently, Professor Doonan and his colleagues pioneered an emerging area in MOF science termed ‘Biomimetic mineralization.’1 This strategy describes the facile, ‘one-pot,’ approach to encapsulating biomacromolecules within MOF crystals. They showed that the methodology is highly versatile by demonstrating the encapsulation of proteins, metalloenzymes, carbohydrates, and DNA within MOFs.1,2 A key finding of our research is that the MOF architecture protects enzymes from external environments that would typically lead to degradation and loss of native activity. Their recent work has shown that understanding the surface chemistry of the protein and MOF is crucial to the development of this new area of MOF research.
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Christian Doonan
Christian Doonan received his Ph.D. from the University of Melbourne and then undertook Post Doctoral research at UCLA. He is now Professor of Chemistry and Director of the Centre for Advanced Nanomaterials. Selected awards: Australian Research Council Future Fellowship, Chemical Society of Japan International Lectureship award, Japan-Australia Emerging Leaders Award. His research interests include applications of porous materials for heterogeneous catalysis and biotechnology. In particular, the encapsulation of biomacromolecules to enhance their stability in conditions required for commercial biocatalysis and non-cryogenic storage and transport.
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