Where: Bldg 20, Auditorium
Description
A keynote lecture by George Gokel, Distinguished Professor of Science Chemistry and Biochemistry and Associate Director of the Center for NanoScience at the University of Missouri-St. Louis. Introduction by Professor Khaled Salama, co-Chair of WEP 2020.
EVENT DESCRIPTION
Supramolecular chemistry has led to a remarkable array of compounds having novel properties. In addition, many new materials have emerged from studies in this area. Although a number of biological properties have been manifested by supramolecular compounds, this remains an understudied area. Our efforts to develop synthetic ion transporters resulted in compounds that show a range of biological activities. In particular, the synthetic ion channels that we call hydrophilic show anti-bacterial activity, but they also show considerable activity as adjuvants that enhance the potency of antibiotics and even reverse resistance of some organisms to those drugs. Three structurally different classes of compounds have been designed, prepared, and studied that show potential as antimicrobials.
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George Gokel
George Gokel is a Distinguished Professor of Chemistry and Biology in the Department of Chemistry at the University of Missouri-St. Louis. Professor Gokel’s early work was in the area of phase transfer catalysis, and he co-authored the first monograph in that field in 1978. He invented the compounds known as “lariat ethers.” During the past ten years, Professor Gokel has pioneered the development of synthetic cation channels that function in phospholipid bilayer membranes. His research work has produced more than 300 papers and a dozen patents. He has authored, co-authored, or edited fifteen books.
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