Where: Bldg 20 Auditorium
Description
The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master clock located within the suprachiasmatic nucleus (SCN) in the hypothalamus operates as an 'orchestra director' for peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals coordination and communications between clocks and their alteration under nutritional challenges. The molecular language of these regulatory pathways implicates the interplay between metabolic cycles and epigenetic control.
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About the speaker
Paolo Sassone-Corsi, is the Director, Center for Epigenetics and Metabolism, University of California, Irvine. Dr. Sassone-corsi's major interest is concentrated on the mechanisms of signal transduction able to modulate nuclear functions and, in particular, gene expression, chromatin remodeling, and epigenetic control. These events have important consequences for the understanding of cellular proliferation, oncogenesis, and differentiation.
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Paolo Sassone-Corsi
Director, Center for Epigenetics and Metabolism, University of California, Irvine. Dr. Sassone-corsi's major interest is concentrated on the mechanisms of signal transduction able to modulate nuclear functions and, in particular gene expression, chromatin remodeling and epigenetic control. These events have important consequences for the understanding of cellular proliferation, oncogenesis and differentiation.
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