Where: Bldg 9, Lecture Hall 2322
Description
A comparative and evolutionary genomics approach has become essential for understanding the underlining mechanism of the life phenomena. But when genomics represents the study of not only genomic information but also gene expression and its regulatory network, the data produced by this approach becomes enormous and complex. For example, microorganism diversity in the Red Sea is studied by metagenomic comparison with other seas in the world. Brain evolution is examined by gene expression comparisons in the neural system among species. Genomes of plants possibly grown in the desert may be compared with those of agricultural plants. Somatic mutations in the cancer cells are traced by genomic comparison between single cells in cancerous tissues. When such big data is produced, how can computational biology deal with it? Prof. Gojobori challenges Prof. Bajic by presenting actual big data problems. Prof. Bajic boldly accepts his challenge by manifesting possible solutions from computational biology.
Takashi Gojobori
Prof. Gojobori is a molecular biologist, he is a Foreign Honorary Member of the American Academy of Arts and Sciences (2006) and Fellow of the American Association for the Advancement of Science (AAAS) (2005). In 2006 Pope Benedict XVI appointed Prof. Gojobori as a member of the Pontifical Academy of Sciences. He has received the Gaetano Salvatore Gold Medal from Italy (2004). He was awarded the Kihara Memorial Foundation Academic Award in 1995 and the Purple Ribbon Medal and the Medal of Honor of Japan in 2009 for a series of his researches to pioneer the early age of “Molecular Evolutionary Studies using Genome Information”
He is the Founding Editor of the journal Genome Biology and Evolution, the Executive Editor of the journal Gene, Academic Editor of FEBS Letters, Associate Editor of Molecular Biology and Evolution and PLOS Genetics, and Section Editor of Computer Genomics in BMC Genomics. He has served on the editorial boards of 6 international journals including GigaScience. Previously he was the Editor of Journal of Molecular Evolution for 8 years (1995–2003). He is leader of the Japanese team of the H-Invitational international consortium who was tasked with creating a database linking the 21,037 validated human genes to their biological function
Gojobori has worked extensively on the rates of synonymous and non-synonymous substitutions, positive selection, horizontal gene transfer, viral evolution, genome evolution, and comparative gene expression. In recent years, he has focused on the evolution of the brain and Central nervous system.
Gojobori has served as the Program Director of the Council for Science and Technology Policy (CSTP) of the Government of Japan and is the Science Officer of the Ministry of Education, Science, Sports, Culture, and Technology (MEXT). He has contributed to the DDBJ/GenBank/EMBL database construction as well as the H-Invitational human gene database.
Vladimir Bajic
Dr. Bajic is Director of CBRC. His primary interest is in facilitating biological discoveries by bioinformatics combined with data modeling and machine learning. Emphasis is on inference of new information in biological data, development of systems with such capabilities on HPC and cloud computing. Other interests: synthetic biology simulation models, optimization of metabolic pathways, omics-data analysis, text- & data-mining, cheminformatics, in silico screening for bioactive compounds.
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