Where: Bldg. 9 Classroom # 4125
Description
DNA repair and human disease Our genome is under continuous threat from endogenous and environmental sources. One of the most common forms of DNA damage is breakage to one strand of the DNA double helix; chromosomal single-strand breaks (SSBs). Failure to repair SSBs can block transcription or result in cytotoxic DNA double-strand breaks during DNA replication, causing cell death. Cells have evolved specialized repair toolkits to fix this type of DNA breakage and defects in distinct components of this repair toolkit underpin several human disorders, such as degenerative disease and cancer. We will present an overview of the molecular architecture of this process and its impact on human health.
Sherif El-Khamisy
Sherif El-Khamisy received his Ph.D. from the University of Sussex in 2005 and was offered the professorial title from the UK in 2012. He subsequently led an initiative to establish the Genome Center at Zewail City. El-Khamisy employs a combination of mammalian and non-mammalian systems, yeast genetics, molecular, cellular, biochemical, and whole animal approaches to unravel the mechanisms of repairing oxidative and protein-linked DNA breaks, and determine their impact on human health. His work has resulted in widely cited publications including papers in Cell, Nature, and Nature sister journals. El-Khamisy’s work was the first to report that defects in repairing faults in one strand of DNA can lead to neurodegeneration. He and his colleagues discovered a novel human enzyme in 2009. Driven by his initial training as a pharmacist, El-Khamisy is leading initiatives to translate these findings to the clinic. In recognition of his achievements, El-Khamisy has been selected as a Fellow of the British Higher Education Academy and serves on the editorial board of reputable journals. He is the recipient of the Egyptian National Award in Medical Sciences and the prestigious Fellowship Award from the Wellcome Trust, UK.
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